Environmentally Friendly Procedure Based on Supercritical Fluid
Chromatography and Tandem Mass Spectrometry Molecular
Networking for the Discovery of Potent Antiviral Compounds from
Euphorbia semiperfoliata, J. Nat. Prod, accepté, DOI: 10.1021/acs.jnatprod.7b00113


Neghra A, Lecsö M, Butel M-J, Espindola L.S., Deguin B, Seguin E. Amidochromenes for promising antileishmanial activity. Nat. Prod. Commun. 2017; MS# P587112,


Horner O, Cheap-Charpentier H, Cachet X, Perrot H, Lédion J, Gelus D, Pécoul N, Litaudon M, Roussi F. Antiscalant properties of Hernaria glabra aqueous solution. Desalination. 2017; 409:157-162.


Valli M, Altei W, Dos Santos R N, E C de Lucca Jr, Dessoy M A, Pioli R M, Cotinguiba F, Cachet X, Michel S, Furlan M, Dias LC, Andricopulo AD, Bolzani V S. Synthetic analogue of the natural product piperlongumine as a potent inhibitor of breast cancer cell Line migration. J. Braz. Chem. Soc. 2017; 28:475-484.


Ralambonirina Rasoarivelo TS, Grougnet R, Michel S, Rakotobe Guillou C, Deguin B. Chemical study ofanthospermum emirnense (Rubiaceae). Biochemical Systematics and Ecology. 2017; 70:186-191.


Remeur C, Le Borgne E, Gauthier L, Grougnet R, Deguin B, Poullain C, Litaudon M. HPLC/ELSD quantification and centrifugal partition chromatography isolation of 8-O-acetylharpagide from Oxera coronata (Lamiaceae). Phytochemical Analysis. 2017; 28:242-246.


Largeron M, Fleury MB. A bioinspired organocatalytic cascade for the selective oxidation of amines under air.  Chem. Eur. J. 2017; 23:6763-6767.


Largeron M. Aerobic catalytic systems inspired by copper amine oxidases: recent developments and synthetic applications. Org. Biomol. Chem. 2017; 15: 4722-4730. (Inside Front Cover)


Ortiz S, Dali-Yahia K, Vasquez-Ocmin P, Grougnet R, Grellier P, Michel S, Maciuk A, Boutefnouchet S. Heme-binding activity of methoxyflavones from Pentzia monodiana Maire (Asteraceae), Chemical constituents from the aerial parts of Pentzia monodiana Maire. (Asteraceae).Fitoterapia. 2017; 118:1-5.


Cottet K, Kouloura E, Kristanida M, Wansi J-D, Odonne G, Michel S, Halabalaki M, Lallemand M-C. Comparative Metabolomics study betwenn african and amazonian Symphonia globulifera by LC-Tandem Phytochem. Lett. 2017; http///


MandovaT, Audo G, MichelS, Grougnet R. Assessment of two centrifugal partition chromatography devices. Application to the purification of Centaurium erythraea methanolic extract.Phytochemistry Letters. 2017; DOI:10.1016/j.phytol.2017.04.033




Azevedo L, Faqueti L, Kritsanida M, Efstathiou A, Smirlis D, Franchi Jr, GC, Genta-Jouve G, Michel S,Sandjo, LP, Grougnet R, Biavatti, M. W. Three new trixane glycosides obtained from the leaves of Jungia  sellowii less. using centrifugal partition chromatography. Beilstein J. Org. Chem. 2016; 12:674-683.


Mai HL, Greiner P, Prost E, Lemoine P, Poullain C, Dumontet V, Deguin B, Vo TBH, Michel S, Grougnet R. Triterpenes from the exudate of Gardenia urvillei. Phytochemistry. 2016; 122:193-202.


Nguyen KMH, Largeron M. Catalytic oxidative coupling of primary amines under air: a flexible route to benzimidazole derivatives. Eur. J. Org. Chem. 2016; 2016:1025-1032.


Cottet K, Xu B, Coric P, Bouaziz S, Michel S, Vidal M, Lallemand M-C, Broussy S. Guttiferone A aggregates modulatesilent information regulator 1 (SIRT1) activity. J. Med. Chem. 2016.


Cheap-Charpentier H, Gelus D, Pécoul N, Perrot H, Lédion J, Horner O, Sadoun J,  Cachet X, Litaudon M, Roussi F. Antiscalant properties of Spergularia rubra and Parietaria officinalis aqueous solutions. J. Crystal Growth. 2016; 443:43-49.


Cachet X, Langrand J, Bottai C,  Dufat TH, Locatelli-Jouans C, Nossin C, Boucaud-Maitre D. Detection of aristolochic acids I and II in “Chiniy-trèf”, a traditional medicinal preparation containing caterpillars feeding on Aristolochia trilobata L. in Martinique, French West Indies.Toxicon. 2016; 114:28-30.





Nguyen KMH, Largeron M. A bioinspired catalytic aerobic oxidative C-H functionalization of primary aliphatic amines: synthesis of 1,2-disubstituted benzimidazoles. Chem. Eur. J. 2015; 21:12606-12610.


Nguyen KMH, Schwendimann L, Gressens P, Largeron M. Regiospecific synthesis of neuroprotective 1,4-benzoxazine derivatives through a tandem oxidation-Diels-Alder reaction. Org. Biomol. Chem. 2015; 13:3749-3756.


Largeron M, Fleury MB. A metalloenzyme-like catalytic system for the chemoselective oxidative cross-coupling of primary amines to imines under ambient conditions. Chem. Eur. J. 2015; 21:3815-3820.


Fromentin Y, Cottet K, Kritsanida M, Michel S, Gaboriaud-Kolar N, Lallemand MC. Symphonia globulifera, a widespread source of complex metabolites with potent biological activities. Planta Med. 2015; 81:95-107.


Fomani M, Ngeufa Happi Kouam E, Porée FH, Lallemand MC, Kamdem AF, Wansi JD. A prenylated acridone alkaloid and ferulate xanthone from barks of Citrus medica (Rutaceae). Z. Naturforch. 2015; 70 :71-75.


Cottet K, Fromentin Y, Kritsanida M, Grougnet R, Odonne G, Duplais C, Michel S, Lallemand MC. Isolation of guttiferones from renewable parts of Symphonia globulifera by centrifugal partition chromatography. Planta Med. 2015; 81:1-5.


Cottet K, Neudörffer A, Kritsanida M, Michel S, Lallemand MC, Largeron M. Polycyclic polyprenylated xanthones from Symphonia globulifera: isolation and biomimetic electrosynthesis. J. Nat. Prod. 2015; 78:2136-2140.


Mai LH, Chabot GG, Grellier P, Quentin L, Dumontet V, Poulain C, Espindola LS, Michel S, Vo HTB, Deguin B, Grougnet R. Antivascular and anti-parasite activities of natural and hemisynthetic flavonoids from new, caledonian gardenia species (Rubiaceae). Eur. J. Med. Chem. 2015; 93:93-100.


Vougogiannopoulou K, Angelopoulou MT, Pratsinis H, Grougnet R, Halabalaki M, Kletsas D, Deguin B, Skaltsounis L. Chemical and biological investigation of olive mill waste water secoiridoid lactones. Planta Med. 2015; 81:1205-1212.


Lémus C, Kritsanida M, Canet A, Genta-Jouve G, Michel S, Deguin B, Grougnet R.Cymoside, a monoterpene indole alkaloid with a hexacyclic fused skeleton from Chimarrhis cymosa. Tetrahedron Lett. 2015; 56:5377-5380.


Lémus C, Grougnet R, Njoh Ellong E, Tian W, Adenet S, Rochefort K, Michel S, Dufat H. Phytochemical study of Capraria biflora L. aerial parts (Scrophulariaceae) from Martinique island (French West Indies). Phytochemistry Letters. 2015; 13:194-199.


Chapeland-Leclerc F, Dilmaghani A, Ez-Zaki L, Boisnard S, Da Silva B, Gaslonde G, Porée FH, Ruprich-Robert G. Systematic gene deletion and functional characterization of histidinekinase phosphorelay receptors (HKRs) in the human pathogenic fungus. Aspergillus fumigatus. Fungal Genetics and Biology. 2015; 84:1-11.


Vougogiannopoulou K, Lemus C,  Halabalaki M, Pergola C, Werz O,  Smith III A,  Michel S, Skaltsounis L, Deguin B. One-step semisynthesis of oleacein and the determination as a 5lipoxygenase inhibitor. J. Nat. Prod. 2015; 77:441−445.


Satiraphan M, Thai QD, Sotanaphun U, Sittisombut C, Michel S, Cachet X. A new 3,4-seco-cycloartane from the leaves of Hopea odorata Roxb. Nat. Prod. Res. 2015; 29:1820-1827.


Chirkin E, Atkatlian W, Do Q, Gaslonde T, Dufat TH, Michel S, Lemoine P, Genta-Jouve G, Porée FH. Chiroptical study and absolute configuration of securinine oxidation products. Nat. Prod. Res. 2015; 29:1235-1242.


Chirkin E, Michel S, Porée FH. Viability of a [2+2+1] hetero-Pauson-Khand cycloaddition strategy toward securinega alkaloids : Synthesis of the BCD-ring core of securinine and related alkaloids. J. Org. Chem. 2015; 80:6525-6528.


Kouloura E, Skaltsounis AL, Michel S, Halabalaki M. Ion tree-based structure elucidation of acetophenone dimers (AtA) from Acronychia pedunculata and their identification in extracts by liquid chromatography electrospray ionization LTQ-Orbitrap mass spectrometry. Mass Spectrom. 2015; 50:495-512.


Becerra M, Boutefnouchet S, Córdoba O, Pinto Vitorino, Brehu G, Lamour L, Laimay I, Efstathiou F, Smirlis A, Michel S, Kritsanida M, Flores ML, Grougnet R.Antileishmanial activity of fucosterol recovered from Lessonia vadosa Searles (Lessoniaceae) by SFE, PSE and CPC. Phytochemistry Letters. 2015; 11:418-423.


Corlay N, Lecsö-Bornet M, Leborgne E, Blanchard F, Cachet X, Bignon J, Roussi F, Butel MJ, Awang K, Litaudon M. Antibacterial labdane diterpenoids from Vitex vestita. J. Nat. Prod. 2015; 78:1348-1356.




Gana I, Dugay A, Henriet T, Rietveld I, Bernard M, Guechot C, Teulon J-M, Safta F, Yagoubi N, Céolin R, Do B. Degradation pathways study of the natriuretic and b-adrenoceptor antagonist tienoxolol using liquid chromatography–electrospray ionization multistage mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis. 2014; 96:58–67.


Tian W, Yougnia R, Depauw S, Lansiaux A, David-Cordonnier MH, Pfeiffer B, Kraus-Berthier L, Léonce S,Pierré A, Dufat H, Michel S. Synthesis, antitumor activity, and mechanism of action of benzo[b]chromeno [6,5-g] [1,8] naphthyridin-7-one analogs of acronycine. J. Med. Chem. 2014;57:10329-10342.


Dilmaç AM, Tite T, Tsimilaza A, Lemoine P, Boutefnouchet S, Michel S, Lallemand MC. Alkylation studies of a polyhydroxylated-cyano-piperidine scaffold. Arkivoc. 2014;(iv):24-37.


Cottet K, Genta-Jouve G, Fromentin Y, Odonne G, Duplais C, Michel S, Lallemand MC. Comparative LC-MS- based metabolite profiling of the ancient tropical rainforest tree Symphonia globulifera. Phytochemistry. 2014; 108:102-108.


Lemoine H, Markovic D, Deguin B. Mild and chemoselective lactone ring-opening with (TMS)ONa. Mechanistic studies and application to sweroside derivatives. J. Org. Chem. 2014; 79:4358−4366.


Vougogiannopoulou K, Lemus C, Halabalaki M, Pergola C, Werz O, Smith III AB, Michel S, Skaltsounis L, Deguin B. One-Step semisynthesis of oleacein and the determination as a 5‑lipoxygenase inhibitor. J. Nat. Prod. 2014; 77:441−445.


Lemus C, Koch M, Michel S, Deguin B. Influence of solvents and catalysts on the formation and hydrolysis of polyfunctional enoxysilanes derived from aucubin. Arkivoc. 2014; (iii):184-196. (Article commémoratif sur invitation).


Marković D, Barboux C, Salle de Chou Y, Bettach J, Grougnet R, Deguin B. Centrifugal partition chromatography: efficient tool to access highly polar and unstable synthetic compounds in large scale. RSC Advances. 2014; 4:63254-63259.


Meriane D, Genta-Jouve G, Kaabeche M, Michel S, Boutefnouchet S. Rapid identification of antioxidant compounds of Genista saharae coss. & dur. By combination of DPPH scavenging assay and HPTLC-MS. Molecules. 2014;19:4369-4379.


Genta-Jouve G, Croué J, Weinberg, Cocandeau V, Holderith S, Bontemps N, Suzuki M, Thomas OP. Two-dimensional ultra-high pressure liquid chromatography quadrupole/time-of-flight mass spectrometry for semi-targeted natural compounds identification. Phytochemistry letters. 2014; 10: 3018-3023.


Coralie Audoin, Sanchez AJ, Genta-Jouve G, Alfonso A, Rios L, Vale Carmen, Thomas OP, Botana LM. Autumnalamide a prenylated cyclic peptide from the cyanobacterium phormidium autumnale, acts on SH-SY5Y cells at the mitochondrial level. J. Nat. Prod. 2014; 77:2196-2205.


Khazem M, Gaslonde T, Dumontet V, Poullain C, Litaudon M, Michel S. Cytotoxic turrianes from Kermadecia elliptica: hemisynthesis and biological activities of kermadecin A derivatives.  Phytochemistry letters.10, 2014: 249-254.


De Assis PA, Theodoro PN, De Paula JE, Araújo AJ, Costa-Lotufo LV, Michel S, Grougnet R, Kritsanida M, Espindola LS. Antifungal ether diglycosides from Matayba guianensis Aublet.Bioorg. Med. Chem. Lett. 2014; 24:1414-1416.


Pergola C, Gaboriaud-Kolar N, Jestädt N, König S, Kritsanida M, Schaible AM, Li H, Garscha U, Weinigel C, Barz D, Albring KF, Huber O, Skaltsounis A-L, Werz O. indirubin core structure of glycogen Synthase Kinase-3 inhibitors as novel chemotype for intervention with 5-lipoxygenase. J. Med. Chem. 2014; 57:3715–3723.


Efstathiou A, Gaboriaud-Kolar N, Smirlis D, Myrianthopoulos V, Vougogiannopoulou K, Alexandratos A, Kritsanida M, Mikros E, Soteriadou K, Skaltsounis AL. An inhibitor-driven study for enhancing the selectivity of indirubin derivatives towards leishmanial Glycogen Synthase Kinase-3 over leishmanial cdc2-related protein kinase 3. Parasites & Vectors. 2014; 7: 234/1-12.


Sawasdee K, Chaowasku T, Lipipun V, Dufat TH, Michel S, Jongbunprasert V, Likhitwatayawuid K. Geranylated homogenstisic acid derivatives and flavonols from Miliusa umpangesis. Biochemical Systematics and Ecology. 2014; 54:179-181.


Langrand J, Regnault H, Cachet X, Bouzidi C, Villa A F, Serfaty L, Garnier R, Michel S. Toxic hepatitis induced by a herbal medicine: Tinospora crispa. Phytomedicine. 2014; 21:1120-1123.



Largeron M. Fleury MB. Bioinspired oxidation catalysts. Science. 2013; 339:43-44.


Largeron M. Protocols for the catalytic oxidation of primary amines to imines. Eur. J. Org. Chem.2013; 2013:5225-5235.


Fromentin Y, Gaboriaud-Kolar N, Ndjakou Lenta B, Wansi JW, Buisson D, Mouray E, Grellier P, Loiseau PM, LallemandMC, Michel S. Synthesis of novel guttiferone A derivatives: In-vitro evaluation toward plasmodium falciparum, trypanosoma brucei and leishmania donovani. Eur. J. Med. Chem. 2013; 65:284-294.


Ollivier A, Grougnet R, Cachet X, Meriane D, Ardisson J, Boutefnouchet S, Deguin B. Large scale purification of the SERCA inhibitor thapsigargin from Thapsia garganica L. roots using centrifugal partition chromatography. J. Chromatogr. B. 2013; 926:16–20.


Lemus C, Poleschak M, Gailly S, Desage-El Murr M, Koch M, Deguin B. Lewis acid catalyzed enlargement of cyclic β-Alkoxyenals and one-pots-synthesis of polyfunctional enoxysilanes derived from aucubin with trimethylsilyldiazomethane.Chem. Eur. J. 2013; 19:4686–469.


Myrianthopoulos V, Kritsanida M, Gaboriaud-Kolar N, Magiatis P, Ferandin Y, Durieu E, Lozach O, Cappel D, Soundararajan M, Filippakopoulos P, Sherman W, Knapp S, Meijer L, Mikros E, Skaltsounis AL. Novel inverse binding mode of indirubin derivatives yields improved selectivity for DYRK Kinases ACS. Med. Chem. Lett. 2013; 4:22-26.


Marrelli M, Cachet X, Conforti F, Sirianna R, Chimento A, Pezzi V,Michel S, Giancarlo A, Statti, Menichini F. Synthesis of a new bis(indolyl)methane that inhibits growth and induces apoptosis in human prostate cancer cells. Nat. Prod. Res. 2013; 27:2039-2045.


Sawasdee K, Chaowasku T, Lipipun V, Dufat TH, Michel S, Likhitwitayawuid K. New neolignans and a lignin from miliusa fragrans, and their anti-herpetic and cytoxic activities. Tetrahedron Letters. 2013; 54: 4259-4263.


Sawasdee K, Chaowasku T, Lipipun V, Dufat TH, Michel S, Likhitwitayawuid K. Neolignans from leaves of Miliusa mollis. Fitoterapia. 2013; 85:49-56.


Cachet X, Porée FH, Michel S, Lemoine P. Tetrahydroalstonine. Acta crystallogr. Section E 2013; 69: 1389-1390.


Momo IJ, Dufat TH, Wandji J, Michel S, Chiozem DD. New triterpenoids from the stem bark of Hypodaphnis zenkeri. Nat. Prod. Res. 2013; 27:137-145.


Bosi C F, Rosa DW, Grougnet R, Lemonakis N, Halabalaki M, Skaltsounis AL, Biavatti MW. Pyrrolizidine alkaloids in medicinal tea of Ageratum conyzoides.Rev. Bras. Farmacogn. 2013; 23: 425-432.



Largeron M, Fleury MB. A biologically inspired Cu(I)/topaquinone-like co-catalytic system for the highly  atom-

economical aerobic oxidation of primary amines to imines. Angew. Chem. Int. Ed. 2012; 51:5409-5412.


Kouloura E, Halabalaki M, Lallemand MC, Nam S, Jove R, Litaudon M, Awang K, Hadi HA, Skaltsounis AL. Cytotoxic

prenylated acetophenone dimers from Acronychia pedunculata. J. Nat. Prod. 2012; 75:1270-1276.


Dongfack MDJ, Lallemand MC, Kuete V, Mbazoa CD, Wansi JD, Trinh-van-Dufat H, MichelS, Wandji J. A new sphingolipid and furanocoumarins with antimicrobial activity from Ficus exasperate. Chem. Pharm. Bull. 2012; 60:1072-1075.


Fromentin Y, Grellier P, Wansi. JD, Lallemand MC, Buisson D. Yeast-mediated xanthone synthesis through oxidative intramolecular cyclisation. Org. Lett. 2012; 14:5054–5057.


Martinez CM, Neudörffer A, Largeron M.  A convenient biomimetic synthesis of optically active putative neurotoxic metabolites of MDMA ("ecstasy") from R-(-)- and S-(+)-N-methyl-alpha-methyldopamine precursors. Org. Biomol.Chem. 2012; 10:3739-3748.


Kouloura E, Halabalaki M, Lallemand MC, Nam S, Jove R, Litaudon M, Awang K, Hadi HA, Skaltsounis AL. Cytotoxic prenylated acetophenone dimers from Acronychia pedunculata. J. Nat. Prod. 2012; 75:1270-1276.


Dongfack MDJ, Lallemand MC, Kuete V, Mbazoa CD, Wansi JD, Dufat TH, MichelS, Wandji J. A new sphingolipid and

furanocoumarins with antimicrobial activity from Ficus exasperate. Chem. Pharm. Bull. 2012; 60:1072-1075.


Fromentin Y, Grellier P, Wansi. JD, Lallemand MC, Buisson D. Yeast-mediated xanthone synthesis through oxidative

intramolecular cyclisation. Org. Lett.2012; 14:5054–5057.


Serbetçi T, Birteksöz S, Prado S, Michel S, Tillequin F. Synthesis and antimicrobial activities of some sulphur containing chromene derivatives. Nat. Prod. Commun. 2012; 7:891-894.


Satiraphan M,Pamonsinlapatham P,Sotanaphun U, Sittisombut C, Raynaud F, Garbay C, Michel S, Cachet X. Lupane triterpnes from the leaves of the tropical rain forest tree hopea odorata roxb and their cytotoxic activities. Biochemical Systematics and Ecology. 2012; 44:407-412.


Liu L,Kritsanida M, Magiatis P, Gaboriaud N, Skaltsounis L, Wang Y, Wu J, Nam S, Jove R. A novel 7 bromoindirubin with potent anticancer activity supresses survival of human melanoma cells associated with inhibition of STAT3 and Akt signalling. Cancer Biology and Therapy. 2012; 13:1255-1261.


Grougnet R, Magiatis P, Laborie H, Lazarou D, Papadopoulos A, Skaltsounis AL. Sesamolinol glucoside, disaminyl ether, and other lignans from sesame seeds.J. Agric. Food Chem.2012; 60:108-111. 



Grougnet R, Magiatis, P, Mitaku S, Tillequin F, Skaltsounis, A.-L. Dammarane triterpenes from Gardenia aubryi VIEILL. Helvetica Chimica Acta. 2011; 94:656-661.


Largeron M. Amine oxidases of the quinoproteins family: their implication in the metabolic oxidation of xenobiotics. Ann. Pharm. Fr. 2011; 69:53-61.


Neudörffer A, Mueller M, Martinez CM, Mechan A, McCann U, Ricaurte GA, Largeron M. Synthesis and neurotoxicity profile of 2, 4,5-trihydroxymethamphetamine and its 6-(N-acetylcystein-S-yl) conjugate. Chem. Res. Toxicol. 2011; 24:968-978.


Ralambonirina Rasoarivelo S, Grougnet R, Vérité P, Lecsö M, Butel M-J, Tillequin F, Rakotobe Guillou C, Deguin B. Chemical composition and antimicrobial activity of the essential oils of anthospermum emirnense baker and anthospermum perrieri homolle (rubiaceae). Chem. Biodiversity. 2011; 8:145-153.


Litaudon M, Le Borgne E, Teres P, Deguin B, Bornet Lecso M, Gueritte F. Searching for iridoids from tropical plants: detection, isolation and antibacterial activity. Planta Med. 2011; 77:1343-1344.


Dupeyre G, Lemoine P, Ainseba N, Michel S, Cachet X. A one-pot synthesis of 7-phenylindolo [3,2-a] carbazoles fromindoles and b-nitrostyrenes, via an unprecedented reaction sequence. Org. Biomol. Chem. 2011; 9:7780-7790.


Marrelli M, Conforti F, Stati GA, Cachet X, Michel S, Tillequin F, Menichini F. Biological potential and structure-activity relationships of most recently developed vascular disrupting agents: an overview of new derivatives of natural combretastatin A-4. Curr. Med. Chem. 2011; 18:3035-3081.


Donati L, Leproux P, Prost E, Michel S, Tillequin F, Gandon V, Porée FH. Solvent/base effects in the selective domino synthesis of phenanthridinones that involves high-valent palladium species:  experimental and theoretical studies. Chem. Eur. J. 2011; 17:12809-12819.


Genès C, Lenglet G, Depauw S, Nhili R, Prado S, David-Cordonnier MH, Michel S, Tillequin F, Porée FH. Synthesis and biological evaluation of N-substituted benzo[c]phenantrolines an benzo[c]phenantrolinoes as antiproliferative agents. Eur. J. Med. Chem. 2011; 46:2017-2031.


Gaslonde T, Covello F, Velazquez-Alonso L, Léonce S, Pierré A, Pfeiffer B, Michel S, Tillequin F. Synthesis and cytotoxic activity of benzo[a]acronycine and benzo[b]acronycine substituted on the A ring. Eur. J. Med. Chem. 2011; 46:1861-1873.


Gaslonde T, Léonce S, Pierré A, Pfeiffer B, Michel S, Tillequin F. Tröger's bases in the acronycine, benzo[a]acronycine, and benzo[b]acronycine series. Tetrahedron Letters. 2011; 52:4426-4429.