Martine Largeron (Dr)

Dr Martine Largeron



University of Paris Descartes                                                    Phone: (+33)15373 9646

UMR CNRS 8638                                                                        Email: Cette adresse e-mail est protégée contre les robots spammeurs. Vous devez activer le JavaScript pour la visualiser.

Faculty of Pharmacy of Paris

4 avenue de l’Observatoire

75270 Paris cedex 06, France


Current research interests


Homogeneous catalysis: the emphasis is placed on bioinspired oxidative processes;

Biomimetic electrosynthesis: especially to mimic the biosynthesis of natural products.


Academic appointment


2004-present :Director of Research at the CNRS (Senior Scientist)

         UMR 8638 CNRS-University Paris Descartes




Catalytic oxidative coupling of primary amines under air: A flexible route to benzimidazole derivatives.

Khac Minh Huy Nguyen, Martine Largeron

European  Journal of Organic Chemistry, 2016, 1025-1032.




A Bioinspired catalytic aerobic oxidative C-H functionalization of primary aliphatic amines: synthesis of 1,2-disubstituted benzimidazoles.

Khac Minh Huy Nguyen, Martine Largeron

Chemistry - A European Journal, 2015, 21, 12606-12610 (Hot Paper).


Polycyclic Polyprenylated Xanthones from Symphonia globulifera: Isolation and Biomimetic Electrosynthesis.

Kévin Cottet, Anne Neudörffer, Marina Kritsanida, Sylvie Michel, Marie-Christine Lallemand, Martine Largeron

Journal of Natural Products, 2015, 78, 2136-2140.


Regiospecific synthesis of neuroprotective 1,4-benzoxazine derivatives through a tandem oxidation-Diels-Alder reaction.

Khac Minh Huy Nguyen, Leslie Schwendimann, Pierre Gressens, Martine Largeron.

Organic and  Biomolecular Chemistry, 2015, 13, 3749-3756.


A metalloenzyme-like catalytic system for the chemoselective oxidative cross-coupling of primary amines to imines under ambient conditions.

Martine Largeron, Maurice-Bernard Fleury

Chemistry- A European Journal, 2015, 21, 3815-3820.




Protocols for the catalytic oxidation of primary amines to imines.

Martine Largeron

European  Journal of Organic Chemistry, 2013, 5225-5235 (Microreview).


Bioinspired Oxidation Catalysts.

Martine Largeron, Maurice-Bernard Fleury

Science, 2013, 339, 43-44 (Perspective).




A Biologically inspired Cu(I)/topaquinone-like co-catalytic system for the highly atom economical aerobic oxidation of primary amines to imines.

Martine Largeron, Maurice-Bernard Fleury

Angewandte Chemie International Edition, 2012, 51, 5409-5412.


A convenient biomimetic synthesis of optically active putative neurotoxic metabolites of MDMA “ecstasy” from R-(-)- and S-(+)-N-methyl-a-methyldopamine precursors.

Claire-Marie Martinez, Anne Neudörffer, Martine Largeron

Organic and  Biomolecular Chemistry, 2012, 10, 3739-3748.